Human immunodeficiency virus-reverse transcriptase inhibition and hepatitis C virus RNA-dependent RNA polymerase inhibition activities of fullerene derivatives

Tadahiko Mashino; Kumiko Shimotohno; Noriko Ikegami; Dai Nishikawa; Kensuke Okuda; Kyoko Takahashi; Shigeo Nakamura; Masataka Mochizuki

doi:10.1016/j.bmcl.2004.12.030

Human immunodeficiency virus-reverse transcriptase inhibition and hepatitis C virus RNA-dependent RNA polymerase inhibition activities of fullerene derivatives

Bioorg Med Chem Lett. 2005 Feb 15;15(4):1107-9. doi: 10.1016/j.bmcl.2004.12.030.

Authors

Tadahiko Mashino¹, Kumiko Shimotohno, Noriko Ikegami, Dai Nishikawa, Kensuke Okuda, Kyoko Takahashi, Shigeo Nakamura, Masataka Mochizuki

Affiliation

¹ Kyoritsu University of Pharmacy, Shibakoen 1-5-30, Minato-ku, Tokyo 105-8512, Japan. mashino-td@kyoritsu-ph.ac.jp

PMID: 15686922
DOI: 10.1016/j.bmcl.2004.12.030

Abstract

We examined the human immunodeficiency virus-reverse transcriptase and hepatitis C virus RNA-dependent RNA polymerase inhibition activities of cationic, anionic, and amino acid-type fullerene derivatives. Among the fullerene derivatives, the amino acid-type fullerene derivative was the most efficient in human immunodeficiency virus-reverse transcriptase inhibition.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antiviral Agents / chemistry
Antiviral Agents / pharmacology
Enzyme Inhibitors / chemistry
Enzyme Inhibitors / pharmacology
Fullerenes / chemistry*
Fullerenes / pharmacology
HIV Reverse Transcriptase / drug effects
Hepacivirus / enzymology*
Humans
Inhibitory Concentration 50
RNA-Dependent RNA Polymerase / antagonists & inhibitors*
Reverse Transcriptase Inhibitors / chemistry*
Reverse Transcriptase Inhibitors / pharmacology
Structure-Activity Relationship

Substances

Antiviral Agents
Enzyme Inhibitors
Fullerenes
Reverse Transcriptase Inhibitors
RNA-Dependent RNA Polymerase
HIV Reverse Transcriptase